Agenerase™ (amprenavir)

A study testing the antiviral effectiveness of low-dose Agenerase™ with Norvir™ (ritonavir) added.

 

Background

The standard dose of Agenerase™ requires individuals to take large numbers of pills. Norvir™ has been shown to lengthen the time that Agenerase™ stays in the blood. In theory, that might mean that Norvir™ can increase the potency of a small amount of Agenerase™ .
Objective
To determine whether the addition of low dose Norvir™ to lower, experimental dose Agenerase™ will be as effective as the higher, standard dose of Agenerase™ .

 

Study Design

Volunteers will be assigned to one of two study groups:

Group 1: Volunteers will receive 1200 mg of Agenerase™ . At least 2 additional anti-HIV medications will be prescribed.

Group 2: Volunteers will receive 600 mg of Agenerase™ and 100 mg of Norvir™. At least 2 additional anti-HIV medications will be prescribed.

Inclusion
Criteria
• Two kinds of volunteers are needed:
  1. Volunteers who have taken or are taking anti-HIV medications.
  2. Volunteers who have never taken anti-HIV medications before.

• T-cell count greater than 50

• HIV+ male or female

• If female, not pregnant and willing to use contraceptives for the duration of the study.


Status
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Enrolling
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For more information about participating in this study in the Los Angeles area, please call 310/358.2429 or e-mail Corie Castro at ccastro@aidsresearch.org

We encourage participation by women and people of color.

This ad was reviewed and approved by the AIDS Research Alliance Institutional Review Board in December, 2000.

 


 

 

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